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Molecular Chemist
About Celsee

Celsee, Inc. is harnessing the gentle power of gravity to break down barriers in single-cell analysis.  The Genesis System’s unparalleled capture and viability rates enable scientists to analyze molecular signatures from hundreds to millions of cells, uniquely allowing the process of two Slide Technologies for improved results across applications such as single-cell cytometry, single-cell proteogenomics, single-cell transcriptomics, rare-cell enumeration, and immune monitoring. This groundbreaking technology can achieve accurate biological insight by capturing more cells and provides a practical, scalable, and efficient approach to analyze rare cells. It is open and customizable to support method and application development as well as protocol optimization. Why choose Celsee? Because Every Cell Matters.

Job Description & Responsibilities

Lead development of novel chemistries for Celsee’s comprehensive single-cell analysis technologies, the Molecular Chemist will innovate unique chemistries and protocols for single-molecule detections and characterizations for high throughput single-cell analysis.

Lead development and optimization of library prep chemistries for Celsee’s novel single cell sequencing preparation protocol.
Lead development and optimization of novel surface chemistry methods, including development of new polymers.
Development of barcoded microspheres for capture of specific molecules (DNA, RNA or proteins) from single cells.
Lead collaborations with external partners for developing and manufacturing modified nucleotides, engineered polymerases, polymers, peptides, oligonucleotides, and related chemistry.
Preparation and purification of synthetic RNA and chemically modified synthetic RNA using automated solid-phase synthesis techniques.
Develop and optimize synthetic protocols and purification protocols.
Document and organize the data generated into clear and easy to read reports
Development of new prototypes and intellectual property

Please note: duties, responsibilities, and activities may change at any time with or without notice.


A Ph.D. in a field such as Biochemistry, Nucleic Acid Enzymology, or related field, as well as

5+ years of Research & Development (R&D) in the area of chemistry development.
Prior experience with nucleic acid chemistry and polymerase enzymology.
Prior experience with polymer and surface chemistry development.
Prior experience with nucleotide synthesis, photochemistry, DNA/RNA labeling and purifications, DNA/RNA single molecule analysis
Knowledge of NGS technology and methods.
Prior experience of standard molecular biology techniques (PCR, electrophoresis) required.
Experience in start-up environments is a plus.
Ability to perform under pressure and adapt to changes (e.g., priorities and timelines) and to work in a fast-paced and quickly changing environment.
Strong interpersonal skills and communication skills for working on cross-functional multi- disciplinary teams, and ability to clearly present experimental results and analysis to multi- disciplinary teams.
Excellent verbal and written communication skills
Proven ability to manage and prioritize multiple, diverse projects simultaneously.
Must be flexible, independent and self-motivated.
Punctual, regular and consistent attendance.

Job Benefits

The Celsee Experience includes flexible work schedules, health benefits, and the ability to work remotely.

Additional benefits include:
Paid time off
Health, prescription, dental and vision insurance
Flexible Spending Account (FSA) and Health Savings Account (HSA)
Short and Long Term Disability insurance.

*Celsee, Inc. is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status or any other characteristic protected by law.

Position: Molecular Chemist

Thank you for your interest in the Molecular Chemist position. Your application has been submitted. Only qualified candidates will be contacted.

Job Rec #



Research & Development

Employment Type
Full Time, Exempt
Job Location
On-site; 100 Phoenix Drive, Ann Arbor, Michigan, 48108
Working Hours
9:00 AM - 5:00 PM
Date posted
July 22, 2019
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