The Genesis System
The Genesis System enables scientists to analyze and interpret cellular behavior and to collect previously inaccessible cell-based information for improved results in applications such as single-cell cytometry, single-cell proteogenomics, single-cell transcriptomics, rare-cell enumeration, and immune monitoring. Whether studying hundreds or millions of cells the Genesis System provides a practical, scalable, and efficient approach to accurately analyze previously undetectable or rare cells.
Meet the Genesis System
The Genesis System enables a range of single-cell applications with Celsingle™ Slides supporting hundreds to millions of cells per experiment. Throughput is flexible across one or two Celsingle Slides per run, which includes a semi-automated workflow through on-instrument reverse transcription. The Genesis System is also an open and customizable system that supports method development and protocol optimization to develop your own applications.
Celsingle Technology
Celsingle™ Slides capture and isolate single cells with a gentle, gravity-based approach. Discrete microwells allow a single cell to be paired with a unique cellular barcode and unique molecular indices for desired applications, such as gene expression or protein quantitation. The Celsingle process is open to support users that want to optimize, modify, or create new single cell applications. The scalability of this approach is unmatched and has the potential to provide a 10x increase in cell throughput compared with other technologies. The Celsingle Slide design enables unique possibilities, including visualization and QC of cells prior to lysis, as well as treatment or challenge of cells.
Key Applications
Single-Cell Cytometry
- High-parameter protein analysis
- Limitless protein detection
- No lasers, droplets, heavy metals or harsh processes
Single-Cell Proteogenomics
- Combination protein and RNA analysis
- Limitless protein detection
- mRNA expression
Single-Cell Transcriptomics
- Scalable population resolution
- High efficiency
- mRNA expression
Key Benefits
- Unmatched sample and cell throughput flexibility — supports experiments from hundreds to millions of cells
- Semi-automated workflow — on-instrument lysis and reverse transcription
- Deep and accurate view of cell populations with >70% capture of input cells
- Open system enables development and optimization of custom single-cell protocols
- Open format enables optional visual QC, confirmation of cell capture rates, and cell characterization by microscopy
